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CBD for Alzheimer's: Evidence and Mechanism of Action
Alzheimer's disease is one of those disorders that have proven rather too tough for medical researchers to crack. This neurodegenerative disease, which reportedly kills more people than both prostate and breast cancers combined, has practically rendered all efforts at finding a cure useless.
Yet, here is a condition that has significant adverse effects not only on the sufferer, but also their loved ones.
Although there is still some controversy surrounding its use, cannabidiol (CBD) oil is showing signs of being potentially beneficial to people with Alzheimer's. We discuss how that may be possible in this article.
CBD and Alzheimer's
Cannabidiol, also known as CBD, is one of several dozens of compounds that the cannabis or hemp plant contains. Many do not know much about it because focus in research has mostly been on the psychoactive properties of the plant – this is not one of them.
In more recent years, researchers have started to find that this cannabinoid can be beneficial in a variety of ways to the brain health. Some of these have observed in laboratory settings that CBD can have desirable effects on symptoms of Alzheimer's disease. Literature on the use of cannabinoids for this purpose is limited, though.
Researchers observed in a 2010 review of clinical and preclinical data that there is a relationship between neurodegenerative diseases, including Alzheimer's, and the endocannabinoid system in humans. Cannabinoids are important factors in neuropathology, neurotransmission, and neurobiology of dementias, they noted.
Dementia is a broad term for describing brain diseases that cause gradual decline in mental ability, significant enough to impact daily life. Alzheimer's is responsible for up to 80 percent of cases, according to estimates.
It was also observed in a 2016 published in the International Journal of Molecular Sciences that CBD helped to down-regulate genes that are linked to Alzheimer's disease. The compound inhibited the expression of a key factor in the development of the disorder.
Studies have also found that cannabinoids can help to deal with behavioral symptoms of this disorder, including agitation and aggression.
How Does CBD Oil Work for Alzheimer's?
Cannabinoids interacts with receptors that form part of the endocannabinoid system, which plays a role in diverse physiological processes, including appetite regulation, memory, mood, and pain sensation.
The endocannabinoid system features cannabinoid receptors. The two main types are cannabinoid types 1 and 2, also known as CB1 and CB2 receptors. CB1 receptors are found in the brain, especially the hippocampus, which you use for learning and memory. As for CB2 receptors, these are mainly present in microglia, which are specialized immune cells.
While THC targets mainly the CB1 receptors, CBD binds equally well to both CB1 and CB2 receptors. It is, therefore, both able to stimulate the activity of CB1 receptors and to control the effect from getting out of hand.
Researchers know that the hippocampus is susceptible to some underlying causes of Alzheimer’s. This explains the memory and learning issues that people with the disorder usually experience. By promoting CB1 receptor activity, cannabidiol may be beneficial to patients.
The cannabinoid also helps with its effect on the CB2 receptors. Early evidence suggests that issues with the microglia are a factor in the development of Alzheimer’s disease.
How to Use CBD Oil for Alzheimer’s
There is no standard dose of cannabidiol for treatment of people with Alzheimer’s. This is primarily because there are yet no significant, gold standard human studies. Societal perception of the cannabis plant contributes to lack of extensive research.
People who advocate use of CBD oil for Alzheimer’s disease thinks the extent of the disorder will be a key factor in the amount to use. They, however, claim that it is not practicable to overdose with the cannabinoid, although that’s no excuse to use it excessively.
It is advised that you start with a high dosage for the first few weeks of treatment with CBD oil. There are reports of Alzheimer’s patients using more than 300 mg daily at the start. We think that’s rather high; maybe it’s for advanced cases.
You may start with a dose of 50 mg. This could be doubled about three days later if you do not see a significant improvement.
The dosage may be reduced after about three weeks to around 30 mg a day.
Better still, stick strictly with the instructions provided by the manufacturer of whatever product you buy.
Purchasing CBD Oil
Some buyers think that cannabidiol always come from the marijuana plant. For this reason, they are reluctant about using it or confused about the legality. The plant is known for its mind-altering effects.
But CBD oil also comes from industrial hemp. This plant contains very negligible amount of the psychoactive THC. Cannabidiol from this source can be sold in most states in the United States, including where cannabis is illegal.
REFERENCES
CBD Oil for Alzheimers, Dosage, Studies & Patient Success Stories (https://idweeds.com/cbd-alzheimers/)
Cannabis and dementia | Alzheimer's Society (https://www.alzheimers.org.uk/about-dementia/treatments/alternative-therapies/cannabis-and-dementia)
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